RESEARCH-GRADE SR-17018 · CAS 2134602-45-0
Break the Chains of Dependence
You're not alone. Thousands of people are navigating kratom and 7-OH withdrawal right now. We've built the tools, community, and resources to support you on your journey forward—at your own pace. We're in recovery ourselves. SR-17018 has helped free many of our customers who were daily 7-OH and kratom users for years.
The Compound
What Is SR-17018?
SR-17018 (CAS 2134602-45-0) is a synthetic, G-protein biased mu-opioid receptor agonist originally developed at the Scripps Research Institute. Unlike conventional opioids, it selectively activates G-protein signaling pathways while minimizing beta-arrestin recruitment — a profile associated with reduced tolerance development in preclinical models.
Researchers have investigated SR-17018 in the context of opioid dependence, kratom alkaloid tolerance (including 7-hydroxymitragynine / 7-OH), and withdrawal symptom models. It is supplied exclusively as a research compound.
Compound Specifications
| CAS Number | 2134602-45-0 |
| IUPAC Name | SR-17018 |
| Purity | ≥99% (HPLC verified) |
| Form | Crystalline Powder |
| Molecular Weight | ~400 g/mol |
| Receptor Target | μ-Opioid Receptor (MOR) |
| Mechanism | G-protein biased agonist |
| Storage | Cool, dry, light-protected |
| Analysis | 3rd-party per batch |
| COA | Included with every order |
Research Context
SR-17018 in Kratom & Opioid Dependence Research
The research community has increasingly studied SR-17018 alongside kratom-derived alkaloids — particularly 7-hydroxymitragynine (7-OH) — due to their shared mu-opioid receptor activity.
Kratom & Mitragynine
Mitragynine and its active metabolite 7-hydroxymitragynine (7-OH) act on mu-opioid receptors, producing tolerance and dependence profiles similar to classical opioids. Researchers have explored SR-17018 as a tool compound in these models due to its biased signaling profile.
7-Hydroxymitragynine (7-OH)
7-OH is the primary active metabolite of kratom and is significantly more potent than mitragynine at the mu-opioid receptor. SR-17018's G-protein bias and tolerance-reversing properties make it a subject of interest in 7-OH dependence research.
Opioid Tolerance Reversal
Preclinical studies have demonstrated that SR-17018 can reverse opioid tolerance through an atypical receptor phosphorylation mechanism. This property distinguishes it from buprenorphine and methadone in research settings.
Why SR17Direct
Quality You Can Verify
Third-Party Tested
Every batch undergoes independent HPLC and NMR analysis. Full certificates of analysis included.
≥99% Purity
Research-grade synthesis verified by accredited laboratories. Consistent quality across every order.
Strict QC Standards
Manufactured following rigorous quality protocols. Full batch traceability for your records.
COA With Every Order
Transparent analytical documentation accompanies every shipment — no exceptions.
Crypto Payments
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Research Grade Only
Supplied exclusively for legitimate laboratory and scientific research applications.
Free Recovery Tools
Your Path to Zero.
One Day at a Time.
SR17Direct isn't just a supplier — we're a recovery resource. Our free, research-grounded tools help you plan and track an SR-17018-assisted taper with the same logic used by the community-developed Google Sheets protocol.
Why a Taper Protocol Works
Calibration Phase
Start low to establish your baseline response before committing to a full protocol.
Maintenance Phase
Hold at a stable dose to allow your receptors to normalize before beginning reduction.
Taper Phase
Gradually reduce your dose on a schedule your body can adapt to — minimizing withdrawal.
All tools are free, require no account, and store no personal data. Your protocol stays on your device.
Community Experiences
What Researchers Are Saying
Anonymous accounts from the research community. Unverified. For informational purposes only.
"After struggling with a severe 7-hydroxymitragynine habit, I decided to try SR-17018 as a last resort. Within a week, I was completely free — with almost none of the withdrawal I had come to dread."
"I spent sixteen years cycling through various opioid dependencies. After using SR-17018 for just over a week, I was able to walk away from all of it. Two weeks later, I'm still clean."
"I had been on Suboxone for over a year and dreaded the idea of tapering. With SR-17018, I simply made the switch, used it for five days, and then stopped everything. A month later, I'm still free."
Get Started Today
Research-Grade SR-17018.
Recovery-Focused Tools.
Order analytically verified SR-17018 with COA included, or start with our free taper calculator — no account required.
For research use only · Not for human consumption · COA included with every order